The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 2014
Filed:
Mar. 07, 2014
Applicant:
University of Maryland, Baltimore, Baltimore, MD (US);
Inventor:
Steven Fletcher, Baltimore, MD (US);
Assignee:
University of Maryland, Baltimore, Baltimore, MD (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/395 (2006.01); C07D 498/00 (2006.01); C07C 237/34 (2006.01); C07C 237/30 (2006.01);
U.S. Cl.
CPC ...
C07C 237/34 (2013.01); C07C 237/30 (2013.01);
Abstract
Small-molecule scaffolds based on 1,2-diphenylacetylene that accurately replicate the spatial and angular projections of several side chains on both faces of an α-helix, specifically the i and i+7 side chains on one face, and the i and i+2 side chains on the other. The amphipathic α-helix mimetic can be used to disrupt disease-promoting protein-protein interactions that are mediated by α-helices.