The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 02, 2014

Filed:

Jun. 06, 2013
Applicant:

Millennium Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Stephen Critchley, Braintree, MA (US);

Courtney A. Cullis, Bedford, MA (US);

Steven P. Langston, North Andover, MA (US);

Hirotake Mitzutani, Cambridge, MA (US);

Edward J. Olhava, Newton, MA (US);

Stephane Peluso, Natick, MA (US);

Irache Visiers, Arlington, MA (US);

Stepan Vyskocil, Arlington, MA (US);

Gabriel S. Weatherhead, Tewksbury, MA (US);

Assignee:

Millennium Pharmaceuticals, Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 473/34 (2006.01); A61K 31/4188 (2006.01); A61K 31/4353 (2006.01); C07D 473/30 (2006.01); C07D 213/69 (2006.01); C07D 239/42 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 471/04 (2006.01); C07D 471/08 (2006.01);
U.S. Cl.
CPC ...
C07D 473/30 (2013.01); C07D 487/04 (2013.01); C07D 213/69 (2013.01); C07D 239/42 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 473/34 (2013.01);
Abstract

This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.


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