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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8901119 B1

PDFFull Text
Date of Patent:
Dec. 02, 2014

Filed:

Mar. 09, 2012

Peptide deformylase inhibitors

Applicants:

Kelly M. Aubart, Collegeville, PA (US);

Andrew B. Benowitz, Collegeville, PA (US);

Yuhong Fang, Eagleville, PA (US);

James Hoffman, Ardmore, PA (US);

Joseph M. Karpinski, Stowe, PA (US);

Andrew Nicholson Knox, Philadelphia, PA (US);

Xiangmin Liao, Collegeville, PA (US);

Donghui Qin, Collegeville, PA (US);

Dongchuan Shi, Collegeville, PA (US);

Jared T. Spletstoser, Collegeville, PA (US);

Inventors:

Kelly M. Aubart, Collegeville, PA (US);

Andrew B. Benowitz, Collegeville, PA (US);

Yuhong Fang, Eagleville, PA (US);

James Hoffman, Ardmore, PA (US);

Joseph M. Karpinski, Stowe, PA (US);

Andrew Nicholson Knox, Philadelphia, PA (US);

Xiangmin Liao, Collegeville, PA (US);

Donghui Qin, Collegeville, PA (US);

Dongchuan Shi, Collegeville, PA (US);

Jared T. Spletstoser, Collegeville, PA (US);

Assignee:

GlaxoSmithKline Intellectual Property (No. 2) Limited, Brentford, Middlesex, GB;

Attorneys:

Grace C. Hsu

John Lemanowicz

Primary Examiner:

Samantha Shterengarts

Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/52 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/4375 (2006.01); A61K 31/4427 (2006.01); A61K 31/427 (2006.01); A61K 31/42 (2006.01); A61K 31/4155 (2006.01); A61K 31/415 (2006.01); A61K 31/4245 (2006.01); C07D 413/02 (2006.01); C07D 401/02 (2006.01); C07D 403/02 (2006.01); C07D 473/00 (2006.01); C07D 239/20 (2006.01); C07D 241/10 (2006.01); C07D 471/04 (2006.01); C07D 217/00 (2006.01); C07D 215/00 (2006.01); C07D 277/20 (2006.01); C07D 233/02 (2006.01); C07D 231/02 (2006.01); C07D 401/12 (2006.01); C07K 5/078 (2006.01); C07D 403/12 (2006.01); C07D 231/06 (2006.01);
U.S. Cl.
CPC ...
C07K 5/06139 (2013.01); C07D 401/12 (2013.01); C12Y 305/01088 (2013.01); C07D 403/12 (2013.01); C07D 231/06 (2013.01);
Abstract

The present invention relates to a compound of Formula (I): ora pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.

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