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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8901111 B1

PDFFull Text
Date of Patent:
Dec. 02, 2014

Filed:

Jun. 04, 2010

Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase

Applicants:

J. Guy Breitenbucher, Escondido, CA (US);

Mark S. Tichenor, San Diego, CA (US);

Jeffrey E. Merit, Stanford, CA (US);

Natalie A. Hawryluk, San Diego, CA (US);

Alison L. Chambers, San Diego, CA (US);

John M. Keith, San Diego, CA (US);

Inventors:

J. Guy Breitenbucher, Escondido, CA (US);

Mark S. Tichenor, San Diego, CA (US);

Jeffrey E. Merit, Stanford, CA (US);

Natalie A. Hawryluk, San Diego, CA (US);

Alison L. Chambers, San Diego, CA (US);

John M. Keith, San Diego, CA (US);

Assignee:

Janssen Pharmaceutica NV, , BE;

Attorney:

Mary A. Appollina

Primary Examiner:

Kendra D Carter

Assistant Examiner:

Jason A Deck

Int. Cl.
CPC ...
A61K 31/616 (2006.01); C07D 401/12 (2006.01); C07D 405/14 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01); A61K 31/5025 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/4439 (2006.01); A61K 31/437 (2006.01); C12N 9/99 (2006.01); A61P 25/04 (2006.01); A61P 29/00 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/00 (2006.01); A61P 25/14 (2006.01); A61P 25/28 (2006.01); A61P 25/08 (2006.01); A61P 25/16 (2006.01); A61P 1/08 (2006.01); A61P 15/00 (2006.01); A61P 27/06 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61P 1/12 (2006.01); A61P 19/02 (2006.01); A61P 9/12 (2006.01); A61P 35/00 (2006.01); A61P 3/10 (2006.01); A61P 17/04 (2006.01); A61P 19/10 (2006.01); A61P 3/00 (2006.01); C07D 487/04 (2006.01); C07D 413/12 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 413/12 (2013.01); C07D 401/14 (2013.01); C07D 401/12 (2013.01); C07D 471/04 (2013.01);
Abstract

Certain aryl-substituted heterocyclic urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis).

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