The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2014
Filed:
Jul. 06, 2012
John C. Williams, Monrovia, CA (US);
Ulrich Rodeck, Philadelphia, PA (US);
Joshua M. Donaldson, Lumberton, NJ (US);
Csaba Kari, Rosemont, PA (US);
John C. Williams, Monrovia, CA (US);
Ulrich Rodeck, Philadelphia, PA (US);
Joshua M. Donaldson, Lumberton, NJ (US);
Csaba Kari, Rosemont, PA (US);
City of Hope, Duarte, CA (US);
Thomas Jefferson University, Philadelphia, PA (US);
Abstract
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a cross-masked mAb heterodimer complex is provided, comprising a first masked mAb, comprising a first signal sequence, a first masking epitope sequence, a first linker that is cleavable by a protease specific to a target tissue, and a first antibody or fragment thereof; and a second masked mAb, comprising a second signal sequence, a second masking epitope sequence, a second linker that is cleavable by a protease specific to a target tissue, and a second antibody or fragment thereof.