The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2014
Filed:
Jun. 17, 2011
Violette Renard Recinos, Highland Heights, OH (US);
Betty Tyler, Catonsville, MD (US);
Sarah Brem Sunshine, Pikesville, MD (US);
Henry Brem, Owings Mills, MD (US);
Violette Renard Recinos, Highland Heights, OH (US);
Betty Tyler, Catonsville, MD (US);
Sarah Brem Sunshine, Pikesville, MD (US);
Henry Brem, Owings Mills, MD (US);
Other;
Abstract
The additive effect of combined intracranial carmustine ('BCNU') with intracranial temozolomide ('TMZ'), and particularly in combination with radiation (“XRT”), in the treatment of two rat intracranial glioma models, the 9L gliosarcoma and the F98 glioma, demonstrates that local delivery of both drugs, especially in combination with radiation, is far more effective than delivery of either drug alone or one systemically and one locally, either with or without radiation. The triple therapy showed a significant improvement in survival when compared to controls (p=0.0004), local BCNU (p=0.0043), oral TMZ (p=0.0026), local TMZ (p=0.0105), and the combinations of either BCNU and XRT (p=0.0378) or oral TMZ and local BCNU (p=0.0154).