The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2014
Filed:
Oct. 24, 2011
Applicants:
John Q. Tan, Westfield, NJ (US);
Ronald M. Kim, Summit, NJ (US);
John W. Mirc, Tokyo, JP;
Inventors:
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4439 (2006.01); C07D 401/14 (2006.01); A61K 45/06 (2006.01); C07D 213/72 (2006.01); A61K 31/496 (2006.01); C07D 401/04 (2006.01); A61K 31/4545 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 45/06 (2013.01); C07D 213/72 (2013.01); A61K 31/4439 (2013.01); A61K 31/496 (2013.01); C07D 401/04 (2013.01); A61K 31/4545 (2013.01);
Abstract
This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.