The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 25, 2014

Filed:

Mar. 16, 2007
Applicants:

Naishuo Zhu, Shanghai, CN;

Huaqing LI, Shanghai, CN;

Min Yang, Shanghai, CN;

Inventors:

Naishuo Zhu, Shanghai, CN;

Huaqing Li, Shanghai, CN;

Min Yang, Shanghai, CN;

Assignee:

Fudan University, Shanghai, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/00 (2006.01); A61K 39/29 (2006.01); C07K 14/47 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4705 (2013.01); A61K 38/00 (2013.01); C12N 2730/10134 (2013.01); A61K 39/292 (2013.01); A61K 2039/55516 (2013.01);
Abstract

This invention relates to a HB vaccine enhancing protein, its gene, gene engineering method for expressing this protein, and the application of this method. The cDNA of this protein, which is screened out from human liver cDNA library, is sequenced and then cloned into prokaryotic or eukaryotic (animal or plant) cell for expression of protein coded by the cDNA (for example, cloning into prokaryotic expression carrier and expression in) and purification of the protein. The protein obtained, when used with HB vaccine, can significantly increase the effect of the vaccine, the immune power of HBV carrier, and the titer of antibody. The protein can be used as an adjutant to HB vaccine.


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