The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2014
Filed:
Sep. 04, 2009
Mary L. Houchin, Rockville, MD (US);
Robin H. Lee, San Diego, CA (US);
Hong Qi, San Diego, CA (US);
Greg Oehrtman, San Diego, CA (US);
Robert N. Jennings, San Diego, CA (US);
Scott H. Coleman, San Diego, CA (US);
Mary L. Houchin, Rockville, MD (US);
Robin H. Lee, San Diego, CA (US);
Hong Qi, San Diego, CA (US);
Greg Oehrtman, San Diego, CA (US);
Robert N. Jennings, San Diego, CA (US);
Scott H. Coleman, San Diego, CA (US);
Amylin Pharmaceuticals, LLC, San Diego, CA (US);
AstraZeneca Pharmaceuticals LP, Wilmington, DE (US);
Abstract
The disclosure provides one-component, injectable, sustained release formulations which comprise microspheres containing active pharmaceutical ingredients (e.g., exenatide), wherein the microspheres are suspended in a non-aqueous carrier. The non-aqueous carrier can be an oil, a fractionated oil, triglycerides, diglycerides, monoglycerides, propylene glycol fatty acid diesters, and the like. The formulations offer distinct advantages of long shelf life for the stability and potency of the formulation and sustained release of active pharmaceutical ingredients to reduce the frequency of medication dosing and to increase patient compliance.