The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 18, 2014

Filed:

Aug. 05, 2011
Applicants:

Iontcho Radoslavov Vlahov, West Lafayette, IN (US);

Michael Groaning, West Lafayette, IN (US);

Paul Joseph Kleindl, Lebanon, IN (US);

Hari Krishna R. Santhapuram, West Lafayette, IN (US);

Fei You, West Lafayette, IN (US);

Kevin Yu Wang, Zionsville, IN (US);

Le-cun Xu, West Lafayette, IN (US);

Katheryn Marie Stanford, Lafayette, IN (US);

Allen Ritter, Lafayette, IN (US);

Christopher Paul Leamon, West Lafayette, IN (US);

Inventors:

Iontcho Radoslavov Vlahov, West Lafayette, IN (US);

Michael Groaning, West Lafayette, IN (US);

Paul Joseph Kleindl, Lebanon, IN (US);

Hari Krishna R. Santhapuram, West Lafayette, IN (US);

Fei You, West Lafayette, IN (US);

Kevin Yu Wang, Zionsville, IN (US);

Le-Cun Xu, West Lafayette, IN (US);

Katheryn Marie Stanford, Lafayette, IN (US);

Allen Ritter, Lafayette, IN (US);

Christopher Paul Leamon, West Lafayette, IN (US);

Assignee:

Endocyte, Inc., West Lafayette, IN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/425 (2006.01); C07D 277/04 (2006.01); C07K 5/02 (2006.01); A61K 31/445 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07K 5/02 (2013.01); A61K 31/445 (2013.01); C07D 417/12 (2013.01);
Abstract

Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.


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