The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2014
Filed:
Mar. 15, 2013
Applicant:
Bio-thera Solutions, Ltd., Co., Guangzhou, CN;
Inventor:
Xiaobin Deng, Guangzhou, CN;
Assignee:
Bio-Thera Solutions Ltd., Co., Guangzhou Science City, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 491/12 (2006.01); C07D 498/06 (2006.01); C07D 498/18 (2006.01); C07D 498/08 (2006.01);
U.S. Cl.
CPC ...
C07D 498/18 (2013.01); C07D 498/08 (2013.01);
Abstract
Provided are efficient methods for direct coupling of a maytansinoid with a carboxylic acid to prepare a maytansinoid C-3 ester in high yield using a rare earth metal-based or trifluoromethanesulfonate-based Lewis acid catalyst and a base together with a coupling reagent. Also provided are compositions used in such methods.