The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 18, 2014

Filed:

Mar. 04, 2013
Applicant:

Wellstat Therapeutics Corporation, Gaithersburg, MD (US);

Inventors:

James Dennen O'Neil, Frederick, MD (US);

Shalini Sharma, Gaithersburg, MD (US);

Ramachandran Arudchandran, Germantown, MD (US);

Assignee:

Wellstat Therapeutics Corporation, Gaithersburg, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/41 (2006.01); C07D 257/04 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 257/04 (2013.01); A61K 31/41 (2013.01); A61K 45/06 (2013.01);
Abstract

Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula I. The uric acid-lowering effects of the compounds of this invention are used to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular disease, risk for developing cardiovascular disease, tumor-lysis syndrome, cognitive impairment, early-onset essential hypertension, and-induced inflammation.


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