The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2014
Filed:
Sep. 04, 2009
Hans-ulrich Demuth, Halle/Saale, DE;
Stephan Schilling, Halle/Saale, DE;
Michael Wermann, Halle/Saale, DE;
Holger Cynis, Halle/Saale, DE;
Astrid Kehlen, Halle/Saale, DE;
Daniel Friedrich, Halle/Saale, DE;
Torsten Hoffmann, Halle/Saale, DE;
Kathrin Gans, Halle/Saale, DE;
Jens-ulrich Rahfeld, Lieskau, DE;
Ulrich Heiser, Halle/Saale, DE;
Michael Almstetter, Martinsried, DE;
Robert Sommer, Halle/Saale, DE;
Ulf-torsten Gaertner, Halle/Saale, DE;
Antje Hamann, Dieskau, DE;
Michael Thormann, Martinsried, DE;
Andreas Treml, Martinsreid, DE;
Hans-Ulrich Demuth, Halle/Saale, DE;
Stephan Schilling, Halle/Saale, DE;
Michael Wermann, Halle/Saale, DE;
Holger Cynis, Halle/Saale, DE;
Astrid Kehlen, Halle/Saale, DE;
Daniel Friedrich, Halle/Saale, DE;
Torsten Hoffmann, Halle/Saale, DE;
Kathrin Gans, Halle/Saale, DE;
Jens-Ulrich Rahfeld, Lieskau, DE;
Ulrich Heiser, Halle/Saale, DE;
Michael Almstetter, Martinsried, DE;
Robert Sommer, Halle/Saale, DE;
Ulf-Torsten Gaertner, Halle/Saale, DE;
Antje Hamann, Dieskau, DE;
Michael Thormann, Martinsried, DE;
Andreas Treml, Martinsreid, DE;
Probiodrug AG, Halle/Saale, DE;
Abstract
The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinizing polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.