The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 18, 2014

Filed:

Mar. 12, 2014
Applicants:

Matthias Grauert, Biberach an der Riss, DE;

Ralf Anderskewitz, Laupheim, DE;

Marc Grundl, Biberach an der Riss, DE;

Thorsten Oost, Biberach an der Riss, DE;

Alexander Pautsch, Biberach an der Riss, DE;

Stefan Peters, Biberach an der Riss, DE;

Inventors:

Matthias Grauert, Biberach an der Riss, DE;

Ralf Anderskewitz, Laupheim, DE;

Marc Grundl, Biberach an der Riss, DE;

Thorsten Oost, Biberach an der Riss, DE;

Alexander Pautsch, Biberach an der Riss, DE;

Stefan Peters, Biberach an der Riss, DE;

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 221/22 (2006.01); A61K 31/439 (2006.01); C07D 209/52 (2006.01); A61K 31/403 (2006.01); A61K 31/4045 (2006.01); A61K 31/407 (2006.01); A61K 31/4725 (2006.01); A61K 45/06 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01); C07D 487/08 (2006.01); C07D 491/08 (2006.01);
U.S. Cl.
CPC ...
C07D 209/52 (2013.01); A61K 31/403 (2013.01); A61K 31/4045 (2013.01); A61K 31/407 (2013.01); A61K 31/439 (2013.01); A61K 31/4725 (2013.01); A61K 45/06 (2013.01); C07D 221/22 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 417/12 (2013.01); C07D 487/08 (2013.01); C07D 491/08 (2013.01);
Abstract

This invention relates to bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.


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