IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8889678 B1

PDFFull Text
Date of Patent:
Nov. 18, 2014

Filed:

Jul. 19, 2010

Acyl guanidine derivatives modulating the hedgehog protein signaling pathway

Applicants:

Martial Ruat, Orsay, FR;

Hélène Faure, Gif-sur-Yvette, FR;

Elisabeth Traiffort, Paris, FR;

Hermine Roudaut, Marly-la-Ville, FR;

André Mann, Ostwald, FR;

Angèle Schoenfelder, Lampertheim, FR;

Maurizio Taddei, Monteriggioni, IT;

Fabrizio Manetti, Castelnuovo Berardenga, IT;

Antonio Solinas, Siena, IT;

Inventors:

Martial Ruat, Orsay, FR;

Hélène Faure, Gif-sur-Yvette, FR;

Elisabeth Traiffort, Paris, FR;

Hermine Roudaut, Marly-la-Ville, FR;

André Mann, Ostwald, FR;

Angèle Schoenfelder, Lampertheim, FR;

Maurizio Taddei, Monteriggioni, IT;

Fabrizio Manetti, Castelnuovo Berardenga, IT;

Antonio Solinas, Siena, IT;

Assignees:

Centre National de la Recherche Scientifique, Paris, FR;

Universite de Strasbourg, Strasbourg Cedex, FR;

Attorney:

Alston & Bird LLP

Primary Examiner:

Samantha Shterengarts

Int. Cl.
CPC ...
C07D 295/00 (2006.01); C07D 213/02 (2006.01); C07D 513/02 (2006.01); C07D 209/04 (2006.01); C07D 317/44 (2006.01); C07D 307/02 (2006.01); C07C 239/00 (2006.01); A61K 31/5377 (2006.01); A61K 31/44 (2006.01); A61K 31/429 (2006.01); A61K 31/404 (2006.01); A61K 31/357 (2006.01); A61K 31/34 (2006.01); A61K 31/16 (2006.01); C07D 209/08 (2006.01); A61K 31/155 (2006.01); C07D 317/68 (2006.01); C07D 213/56 (2006.01); C07C 279/22 (2006.01); C07D 513/04 (2006.01); C07D 307/68 (2006.01); C07D 209/14 (2006.01); C07D 295/155 (2006.01); C07D 213/81 (2006.01);
U.S. Cl.
CPC ...
C07C 279/22 (2013.01); C07D 209/08 (2013.01); A61K 31/155 (2013.01); C07D 317/68 (2013.01); C07D 213/56 (2013.01); C07D 513/04 (2013.01); C07D 307/68 (2013.01); C07D 209/14 (2013.01); C07D 295/155 (2013.01); C07D 213/81 (2013.01); C07C 2101/14 (2013.01);
Abstract

The present invention relates to acyl guanidine derivatives modulating the hedgehog protein signaling pathway to be used as drugs, in particular for treating diseases involving a tissue dysfunction associated with a deregulation of the hedgehog protein signaling pathway, as well as to pharmaceutical compositions containing same. The present invention also relates to novel acyl guanidine derivatives as such.

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