The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 18, 2014

Filed:

Jan. 11, 2013
Applicants:

Matthias Grauert, Biberach an der Riss, DE;

Daniel Bischoff, Biberach an der Riss, DE;

Georg Dahmann, Warthausen-Birkenhard, DE;

Raimund Kuelzer, Mittelbiberach, DE;

Klaus Rudolf, Warthausen, DE;

Inventors:

Matthias Grauert, Biberach an der Riss, DE;

Daniel Bischoff, Biberach an der Riss, DE;

Georg Dahmann, Warthausen-Birkenhard, DE;

Raimund Kuelzer, Mittelbiberach, DE;

Klaus Rudolf, Warthausen, DE;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/52 (2006.01); A61K 31/53 (2006.01); A61K 31/5377 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 473/34 (2006.01); C07D 249/08 (2006.01);
U.S. Cl.
CPC ...
C07D 249/08 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/14 (2013.01);
Abstract

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R, R, Rhave meanings given in the description.


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