The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2014
Filed:
May. 16, 2013
Applicant:
Confometrx, Inc., Palo Alto, CA (US);
Inventor:
Brian Kobilka, Palo Alto, CA (US);
Assignee:
ConfometRx, Inc., Palo Alto, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/04 (2006.01); C07K 14/00 (2006.01); C07K 14/72 (2006.01); C12N 9/36 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C07K 14/723 (2013.01); C07K 2319/24 (2013.01); C07K 2299/00 (2013.01); C07K 2319/21 (2013.01); C12N 9/2462 (2013.01); C07K 2319/43 (2013.01); C07K 2319/35 (2013.01); C12Y 302/01017 (2013.01); C12N 2799/026 (2013.01); C07K 2319/00 (2013.01); C07K 14/705 (2013.01); C07K 2319/23 (2013.01);
Abstract
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a family C G-protein coupled receptor (GPCR), wherein the first portion comprises the TM1, TM2 and TM3, regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, wherein the second portion comprises the TM4, TM5 TM6 and TM7 regions of the GPCR.