The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2014
Filed:
Jun. 30, 2011
Applicants:
Dennis T. Brown, Raleigh, NC (US);
Raquel Hernandez, Raleigh, NC (US);
Inventors:
Dennis T. Brown, Raleigh, NC (US);
Raquel Hernandez, Raleigh, NC (US);
Assignee:
Research Development Foundation, Carson City, NV (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); C07K 14/005 (2006.01); C07H 21/04 (2006.01); A61K 39/145 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); C12N 2770/24171 (2013.01); C12N 2770/24122 (2013.01); A61K 39/12 (2013.01); C12N 15/86 (2013.01); C07K 14/005 (2013.01); A61K 2039/525 (2013.01); C12N 2770/24134 (2013.01); C12N 2770/24145 (2013.01); C12N 2770/24162 (2013.01); A61K 2039/5254 (2013.01);
Abstract
Methods and compositions concerning mutant flaviviruses with host-range phenotypes are provided. Nucleotide sequences that encode mutant flavivirus proteins are also provided. In certain aspects, viruses comprising these sequences display reduced replication in mammalian cells. In further aspects of the invention, flavivirus vaccine compositions and methods for vaccination against flavivirus infection are provided.