The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2014
Filed:
May. 28, 2010
Applicants:
Jeffrey Milbrandt, St. Louis, MO (US);
Toshiyuki Araki, Tokyo, JP;
Yo Sasaki, St. Louis, MO (US);
Inventors:
Assignee:
Washington University, Saint Louis, MO (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/51 (2006.01); C12N 9/12 (2006.01); C12N 15/00 (2006.01); A61K 38/50 (2006.01); A61K 31/7084 (2006.01); A61K 38/45 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/45 (2013.01); C12N 9/1241 (2013.01); A61K 48/00 (2013.01); A61K 38/50 (2013.01); A61K 31/7084 (2013.01);
Abstract
Methods of treating or preventing axonal degradation in neuropathic diseases in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts by increasing sirtuin activity in diseased and/or injured neurons. The methods can also comprise administering to the mammal an effective amount of an agent that acts by increasing NAD activity in diseased and/or injured neurons. Also disclosed are methods of screening agents for treating a neuropathies and recombinant vectors for treating or preventing neuropathies.