Differential mobility spectrometer with asymmetrically oscillating driving electrical field

Abstract

A method of operating a differential mobility spectrometer includes an ionization chamber, a filter channel and a detection region. In the ionization chamber, analyte ions are produced from a sample, the so-obtained ions are then subjected in the filter channel to a time-varying electric field. The time-varying electric field has a longitudinal field component drawing the analyte ions from the ionization chamber through the filter channel into the detection region and a transversal field component, which is the superposition of an asymmetrically oscillating transversal field causing the analyte ions to move to and fro in transversal direction and a compensation field for selecting a species of analyte ions by substantially canceling the average transversal velocity of the selected species. Analyte ions of the selected species having passed through the filter channel are collected in the detection region and a detection signal responsive to the number of analyte ions collected is generated as a function of the compensating field. The longitudinal field component oscillates in longitudinal direction in such a way that it imparts to the analyte ions on average a non-zero longitudinal velocity in direction of the detection region while it causes them, on a shorter time scale, to move to and fro in longitudinal direction in the filter channel.