The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
May. 02, 2011
Antonio Abelino DE Leon Martin, Barbera Del Valles, ES;
Jordi Bessa Bellmunt, Barcelona, ES;
Juan Huguet Clotet, Sant Joan Despi, ES;
Lluis Sola Carandell, Tarragona, ES;
Gloria Freixas Pascual, Tarragona, ES;
Jordi Ceron Bertran, Tarragona, ES;
Pere Dalmases Barjoan, Sant Feliu De Llobregat, ES;
Antonio Abelino De Leon Martin, Barbera Del Valles, ES;
Jordi Bessa Bellmunt, Barcelona, ES;
Juan Huguet Clotet, Sant Joan Despi, ES;
Lluis Sola Carandell, Tarragona, ES;
Gloria Freixas Pascual, Tarragona, ES;
Jordi Ceron Bertran, Tarragona, ES;
Pere Dalmases Barjoan, Sant Feliu De Llobregat, ES;
Laboratorios Lesvi, S.L., , ES;
Abstract
The present invention refers to an improved method for the preparation of compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid substantially free of its 3H-I isomer. The invention also refers to the use of said intermediate for the preparation of Rufinamide and for obtaining a new polymorphic form of Rufinamide, designed as Form R-5. The invention also refers to said new polymorph of Rufinamide, and to the composition containing it and its use as medicament. The new polymorph of Rufinamide shows good stability and appropriate physico-chemical properties for its manipulation on industrial scale. Polymorph Form R-5 will be suitable to use as pharmaceutical for the treatment of convulsions, especially for the treatment of epilepsy.