The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
Jan. 20, 2012
Guanghui Tian, Shanghai, CN;
Guan Wang, Shanghai, CN;
Xiaoguang Kong, Shanghai, CN;
Rongxia Zhang, Shanghai, CN;
Weiming Chen, Shanghai, CN;
Jingshan Shen, Shanghai, CN;
Guanghui Tian, Shanghai, CN;
Guan Wang, Shanghai, CN;
Xiaoguang Kong, Shanghai, CN;
Rongxia Zhang, Shanghai, CN;
Weiming Chen, Shanghai, CN;
Jingshan Shen, Shanghai, CN;
Topharman Shanghai Co., Ltd., Shanghai, CN;
Topharman Shandong Co., Ltd., Shandong, CN;
Abstract
Provided is a process for preparing racemic nicotine from 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof using one-pot process. The process comprises the following steps: 1) in a reaction vessel, reacting 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof in the presence of a suitable solvent and a strong acid by heat; after the reaction is complete, cooling the same and adjusting the pH to 7-8 with alkali; and 2) directly adding a reductant into the above vessel, and after the reaction, purifying the product so as to obtain high purity racemic nicotine or a salt thereof.