The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
Nov. 08, 2007
Bruno Canard, Cassis, FR;
Karine Alvarez, Marseilles, FR;
Karine Barral, Marseilles, FR;
Jean-louis Romette, Marseilles, FR;
Johan Neyts, Kessel-Lo, BE;
Jan Balzarini, Heverlee, BE;
Bruno Canard, Cassis, FR;
Karine Alvarez, Marseilles, FR;
Karine Barral, Marseilles, FR;
Jean-Louis Romette, Marseilles, FR;
Johan Neyts, Kessel-Lo, BE;
Jan Balzarini, Heverlee, BE;
Centre National de la Recherche Scientifique-CNRS, Paris, FR;
Universite d'Aix-Marseille, Marseilles, FR;
K.U. Leuven Research & Development, Leuven, BE;
Abstract
This invention relates to a purine or pyrimidine phosphonate compound of formula (I) or pharmaceutically acceptable salt thereof; wherein B, X, and R-Rare as defined in classes and subclasses herein. These compounds may be used as antiviral precursors. The invention also relates to therapeutic compositions of these compounds and their use for the preparation of a medication for testing and/or preventing a viral infection in a patient. The invention also provides methods for making these compounds. In particular, the invention provides an H-phosphinate precursor intermediate of formula (II) wherein B is a purine or pyrimidine base as defined herein and Ris selected from the group comprising a hydrogen atom, and a methyl, ethyl, hydroxymethyl, hydroxyethyl and Chaloalkyl group.