The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
Oct. 14, 2010
Applicants:
Jakub Castulik, Blansko, CZ;
Miroslav Zabadal, Blansko, CZ;
Inventors:
Jakub Castulik, Blansko, CZ;
Miroslav Zabadal, Blansko, CZ;
Assignee:
Synthon BV, Nijmegen, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 241/24 (2006.01); C07F 9/6571 (2006.01); C07F 9/38 (2006.01); C07F 5/02 (2006.01); C07F 5/04 (2006.01);
U.S. Cl.
CPC ...
C07F 9/657163 (2013.01); C07D 241/24 (2013.01); C07F 9/3895 (2013.01); C07F 5/025 (2013.01); C07F 9/657181 (2013.01); C07F 5/04 (2013.01);
Abstract
The invention relates to processes of making bortezomib of formula (1) enantiomers thereof and/or intermediates thereof, comprising at least one step of coupling a carboxylic acid with an amine, wherein the coupling step is performed in a presence of the compound of formula (8), wherein A is C1-C6 alkyl group, preferably wherein A is n-propyl group.