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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8883833 B1

PDFFull Text
Date of Patent:
Nov. 11, 2014

Filed:

Nov. 20, 2008

Substituted benzoazole pde4 inhibitors for treating inflammatory, cardiovascular and cns disorders

Applicants:

Jasbir Singh, Naperville, IL (US);

Mark E. Gurney, Grand Rapids, MI (US);

Alex Burgin, Kingston, WA (US);

Vincent Sandanayaka, Northboro, MA (US);

Alexander Kiselyov, San Diego, CA (US);

Munagala Rao, Westmont, IL (US);

Inventors:

Jasbir Singh, Naperville, IL (US);

Mark E. Gurney, Grand Rapids, MI (US);

Alex Burgin, Kingston, WA (US);

Vincent Sandanayaka, Northboro, MA (US);

Alexander Kiselyov, San Diego, CA (US);

Munagala Rao, Westmont, IL (US);

Assignee:

Decode Genetics EHF, , IS;

Attorney:

Heslin Rothenberg Farley & Mesiti P.C.

Primary Examiner:

Joseph Kosack

Assistant Examiner:

Matthew Coughlin

Int. Cl.
CPC ...
C07D 513/04 (2006.01); C07D 498/04 (2006.01); C07D 417/04 (2006.01); C07D 417/06 (2006.01); C07D 417/14 (2006.01); C07D 277/64 (2006.01); C07D 277/82 (2006.01); C07D 263/56 (2006.01); C07D 263/58 (2006.01); A61K 31/519 (2006.01); A61K 31/496 (2006.01); A61K 31/454 (2006.01); A61K 31/4439 (2006.01); A61K 31/428 (2006.01); A61K 31/423 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); C07D 263/58 (2013.01); A61K 31/454 (2013.01); C07D 277/64 (2013.01); A61K 31/519 (2013.01); C07D 277/82 (2013.01); C07D 498/04 (2013.01); C07D 417/06 (2013.01); A61K 31/496 (2013.01); A61K 31/428 (2013.01); C07D 263/56 (2013.01); C07D 417/04 (2013.01); A61K 31/423 (2013.01); A61K 31/4439 (2013.01); C07D 513/04 (2013.01);
Abstract

The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles. A particular embodiment is

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