The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
Aug. 22, 2011
Lianyun Zhao, Blue Bell, PA (US);
Duan Liu, Arlington, MA (US);
Shuyi Tang, Belmont, MA (US);
Amit K. Mandal, Shrewsbury, MA (US);
Umar Faruk Mansoor, Framingham, MA (US);
Lalanthi Dilrukshi Vitharana, Somerville, MA (US);
Panduranga Adulla P. Reddy, Walpole, MA (US);
M. Arshad Siddiqui, Newton, MA (US);
Lianyun Zhao, Blue Bell, PA (US);
Duan Liu, Arlington, MA (US);
Shuyi Tang, Belmont, MA (US);
Amit K. Mandal, Shrewsbury, MA (US);
Umar Faruk Mansoor, Framingham, MA (US);
Lalanthi Dilrukshi Vitharana, Somerville, MA (US);
Panduranga Adulla P. Reddy, Walpole, MA (US);
M. Arshad Siddiqui, Newton, MA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention relates to certain pyrazolo[1,5-a]pyrimidine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the pyrazolo[1,5-a]pyrimidine compounds.