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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8883798 B1

PDFFull Text
Date of Patent:
Nov. 11, 2014

Filed:

Feb. 27, 2012

Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin e2, method of production thereof and use thereof

Applicants:

Petr Jansa, Lanskroun, CZ;

Zdenek Zidek, Prague, CZ;

Eva Kmonickova, Prague, CZ;

Zlatko Janeba, Prague, CZ;

Ludmila Hola, Prague, CZ;

Inventors:

Petr Jansa, Lanskroun, CZ;

Antonin Holy, Prague, CZ;

Zdenek Zidek, Prague, CZ;

Eva Kmonickova, Prague, CZ;

Zlatko Janeba, Prague, CZ;

Assignees:

Ustav Organicke Chemie a Biochemie Akademie Ved CR, V.V.I., Prague, CZ;

Ustav Experimentalni Mediciny Akademie Ved CR, V.V.I., Prague, CZ;

Attorney:

Notaro, Michalos & Zaccaria P.C.

Primary Examiner:

James O Wilson

Assistant Examiner:

Alexander R Pagano

Int. Cl.
CPC ...
A01N 43/54 (2006.01); C07D 239/42 (2006.01); C07D 401/04 (2006.01); A61K 31/505 (2006.01); C07D 409/04 (2006.01); C07D 239/34 (2006.01); C07D 239/38 (2006.01); C07D 405/04 (2006.01); C07D 239/24 (2006.01); C07D 239/20 (2006.01); C07D 405/14 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); A61K 31/506 (2006.01);
U.S. Cl.
CPC ...
C07D 239/24 (2013.01); A61K 31/505 (2013.01); C07D 409/04 (2013.01); C07D 239/34 (2013.01); C07D 239/38 (2013.01); C07D 405/04 (2013.01); C07D 239/20 (2013.01); C07D 239/42 (2013.01); C07D 405/14 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); A61K 31/506 (2013.01); C07D 401/04 (2013.01);
Abstract

The invention provides pyrimidine compounds of general formula (I), which reduce simultaneously the production of nitric oxide (NO) and prostaglandin E2 (PGE2). They have no negative effect on the viability of cells in concentrations decreasing the production of these factors by up to 50%; they are not cytotoxic. Furthermore, a method of preparation of the pyrimidine compounds of general formula (I), carrying 2-formamido group, a pharmaceutical composition comprising the substituted pyrimidine compounds according to the invention, and the use of these compounds for the treatment of inflammatory and cancer diseases are provided.

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