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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8883793 B1

PDFFull Text
Date of Patent:
Nov. 11, 2014

Filed:

Dec. 29, 2011

Tubulin inhibitors and methods of using the same

Applicants:

Meng-hsin Chen, Westfield, NJ (US);

Shih-hsien Chuang, New Taipei, TW;

Yi-jen Chen, New Taipei, TW;

Lien-hsiang Chang, New Taipei, TW;

Tsung-hui LI, New Taipei, TW;

Ching-hui Chen, New Taipei, TW;

Win-yin Wei, New Taipei, TW;

Inventors:

Meng-Hsin Chen, Westfield, NJ (US);

Shih-Hsien Chuang, New Taipei, TW;

Yi-Jen Chen, New Taipei, TW;

Lien-Hsiang Chang, New Taipei, TW;

Tsung-Hui Li, New Taipei, TW;

Ching-Hui Chen, New Taipei, TW;

Win-Yin Wei, New Taipei, TW;

Assignee:

Development Center for Biotechnology, New Taipei, TW;

Attorney:

Osha Liang LLP

Primary Examiner:

Kristin Vajda

Int. Cl.
CPC ...
A61K 31/426 (2006.01); A61K 31/4439 (2006.01); A61K 31/496 (2006.01); C07D 417/12 (2006.01); C07D 405/12 (2006.01); C07D 277/42 (2006.01); C07D 417/04 (2006.01); C07D 401/04 (2006.01); C07D 409/12 (2006.01); C07D 417/06 (2006.01); C07D 233/88 (2006.01); C07D 417/14 (2006.01); C07D 285/135 (2006.01); C07D 239/42 (2006.01); C07D 213/75 (2006.01); C07D 277/46 (2006.01);
U.S. Cl.
CPC ...
C07D 277/46 (2013.01); C07D 417/12 (2013.01); C07D 405/12 (2013.01); C07D 401/04 (2013.01); C07D 409/12 (2013.01); C07D 417/06 (2013.01); C07D 233/88 (2013.01); C07D 417/14 (2013.01); C07D 285/135 (2013.01); C07D 239/42 (2013.01); C07D 213/75 (2013.01);
Abstract

Compounds represented by the formula (I) or pharmaceutically acceptable salts thereof:R—Y—Z-Q-A-R  Formula (I)wherein R, R, Y, Z, Q, and A are as defined. These compounds are inhibitors of tubulin polymerization by binding at colchicines binding site and are useful in the treatment of tumors or mitotic diseases such as cancers, gout, and other conditions associated with abnormal cell proliferation.

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