The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 11, 2014

Filed:

Feb. 13, 2012
Applicants:

Jacques Bailly, Zimmersheim, FR;

Cornelia Hertel, Brislach, CH;

Daniel Hunziker, Moehlin, CH;

Christian Lerner, Binningen, CH;

Ulrike Obst Sander, Reinach BL, CH;

Jens-uwe Peters, Grenzach-Wyhlen, DE;

Philippe Pflieger, Schwoben, FR;

Tanja Schulz-gasch, Liestal, CH;

Inventors:

Jacques Bailly, Zimmersheim, FR;

Cornelia Hertel, Brislach, CH;

Daniel Hunziker, Moehlin, CH;

Christian Lerner, Binningen, CH;

Ulrike Obst Sander, Reinach BL, CH;

Jens-Uwe Peters, Grenzach-Wyhlen, DE;

Philippe Pflieger, Schwoben, FR;

Tanja Schulz-Gasch, Liestal, CH;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/498 (2006.01); A61K 31/502 (2006.01); A61K 31/4965 (2006.01); C07D 277/24 (2006.01); C07D 277/62 (2006.01); C07D 498/04 (2006.01); C07D 231/12 (2006.01); C07D 233/64 (2006.01); C07D 239/26 (2006.01); C07D 241/12 (2006.01); C07D 401/04 (2006.01); C07D 215/14 (2006.01); C07D 471/04 (2006.01); C07D 213/64 (2006.01); C07D 213/61 (2006.01); C07D 217/16 (2006.01); C07D 401/06 (2006.01); C07D 249/18 (2006.01); C07D 213/30 (2006.01); C07D 237/08 (2006.01);
U.S. Cl.
CPC ...
C07D 241/12 (2013.01); C07D 277/24 (2013.01); C07D 277/62 (2013.01); C07D 498/04 (2013.01); C07D 231/12 (2013.01); C07D 233/64 (2013.01); C07D 239/26 (2013.01); C07D 401/04 (2013.01); C07D 215/14 (2013.01); C07D 471/04 (2013.01); C07D 213/64 (2013.01); C07D 213/61 (2013.01); C07D 217/16 (2013.01); C07D 401/06 (2013.01); C07D 249/18 (2013.01); C07D 213/30 (2013.01); C07D 237/08 (2013.01);
Abstract

The present invention relates to compounds of formula I wherein A, n, Rto Rand Rto Rare as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.


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