The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
Dec. 08, 2010
Applicants:
Ravit Arav-boger, Baltimore, MD (US);
Gary Posner, Baltimore, MD (US);
Inventors:
Ravit Arav-Boger, Baltimore, MD (US);
Gary Posner, Baltimore, MD (US);
Assignee:
The John Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/357 (2006.01); C07D 493/18 (2006.01); C07F 9/6561 (2006.01); A61K 31/683 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/357 (2013.01); A61K 31/683 (2013.01); A61K 45/06 (2013.01); C07D 493/18 (2013.01); C07F 9/6561 (2013.01);
Abstract
Artemisinin-derived monomers and artemisinin dimers are shown to exhibit in-vitro anti-cytomegalovirus (CMV) activity. Artemisinin dimers effectively inhibited CMV replication in human foreskin fibroblasts and human embryonic lung fibroblasts with no cytotoxicity at concentrations required for complete CMV inhibition. Artemisinin dimers were found to be potent and non-cytotoxic inhibitors of CMV replication, which indicates their use as therapeutic agents for the treatment of CMV infection in humans.