The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
Jun. 07, 2013
Marc S. Penn, Beachwood, OH (US);
Rahul Aras, Broadview Heights, OH (US);
Joseph Pastore, Mentor, OH (US);
Timothy J. Miller, Cleveland Heights, OH (US);
Marc S. Penn, Beachwood, OH (US);
Rahul Aras, Broadview Heights, OH (US);
Joseph Pastore, Mentor, OH (US);
Timothy J. Miller, Cleveland Heights, OH (US);
Juventas Therapeutics, Inc., Cleveland, OH (US);
Abstract
Provided herein are methods of treating a cardiomyopathy in a subject by administering directly to, or expressing locally in, a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification. Also provided are methods of treating critical limb ischemia in a subject by administering a DNA plasmid encoding human SDF-1 by direct injection into the affected limb.