The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
Dec. 27, 2007
Chang-yuil Kang, Seoul, KR;
Sanghee Kim, Seoul, KR;
Hyun-jun Youn, Seoul, KR;
Yoon-sook Lee, Yeosu-si, KR;
Kyoo-a Lee, Gyeongju-si, KR;
Taeho Lee, Seoul, KR;
Dong Jae Baek, Seoul, KR;
Minjae Cho, Eujungbu-si, KR;
Chang-Yuil Kang, Seoul, KR;
SangHee Kim, Seoul, KR;
Hyun-Jun Youn, Seoul, KR;
Yoon-Sook Lee, Yeosu-si, KR;
Kyoo-A Lee, Gyeongju-si, KR;
Taeho Lee, Seoul, KR;
Dong Jae Baek, Seoul, KR;
Minjae Cho, Eujungbu-si, KR;
SNU R&DB Foundation, Seoul, KR;
Abstract
Disclosed are novel α-galactosylceramide derivatives, pharmaceutically acceptable salts thereof, preparation methods thereof, and pharmaceutical compositions for use in an immune adjuvant containing the same as an active ingredient. The derivatives, in which the amide moiety of α-GalCer is bioisosterically replaced with a triazole moiety, direct cytokine secretion toward IL-4 rather than IFN-γand thus can be used as a therapeutic for autoimmune diseases regulated by IL-4, such as type 1 diabetes and multiple sclerosis.