The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
Nov. 02, 2012
Applicant:
Novartis Ag, Basel, CH;
Inventors:
David Jenkins, Carlisle, MA (US);
Ming Lei, Acton, MA (US);
Andreas Loew, Somerville, MA (US);
Li Zhou, West Roxbury, MA (US);
Assignee:
Novartis AG, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 35/00 (2006.01); C07K 14/76 (2006.01); C07K 19/00 (2006.01); C12P 21/08 (2006.01); A61K 39/395 (2006.01); C12N 15/09 (2006.01); C12N 15/11 (2006.01); C12N 15/13 (2006.01); C12N 15/14 (2006.01); C07K 16/46 (2006.01); C07K 16/28 (2006.01); C07K 14/775 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/46 (2013.01); A61K 39/39558 (2013.01); A61K 2039/505 (2013.01); C07K 2319/30 (2013.01); C07K 2317/76 (2013.01); C07K 2319/31 (2013.01); C12N 2740/15041 (2013.01); C07K 16/28 (2013.01); C07K 2317/35 (2013.01); C07K 2317/94 (2013.01); C07K 2317/55 (2013.01); C07K 14/775 (2013.01); C07K 2317/622 (2013.01); Y10S 424/809 (2013.01);
Abstract
The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit.