The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
May. 12, 2010
Cyril Y. Bowers, New Orleans, LA (US);
David H. Coy, New Orleans, LA (US);
Simon J. Hocart, New Orleans, LA (US);
Gloria S. Tannenbaum, Hampstead, CA;
Cyril Y. Bowers, New Orleans, LA (US);
David H. Coy, New Orleans, LA (US);
Simon J. Hocart, New Orleans, LA (US);
Gloria S. Tannenbaum, Hampstead, CA;
McGill University, Montreal, CA;
The Administrators of the Tulane Educational Fund, New Orleans, LA (US);
Abstract
The invention provides methods for treatment, prevention or management of obesity, obesity related disorders, diabetes mellitus, and metabolic syndrome in a subject by administering a ghrelin O-acyltransferase (GOAT) inhibitor and/or a ghrelin receptor antagonist to the subject. The invention also provides ghrelin receptor antagonists of formula (VII): A-A-A-Gly-Ser-A-Phe-Leu-A-A-A-A(SEQ ID NO: 93), wherein each of A, A, and Ais independently absent, an amino acid, or an amino protecting group; each of A, A, A, and Ais independently absent or an amino acid; and Ais a serine conjugated with a —(O)C-Calky or a diaminopropionic acid conjugated with a —C(O)C-Calkyl group, provided that at least one of A, A, or Ais present.