The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
Oct. 15, 2008
Thomas Børglum Kjeldsen, Virum, DK;
Morten Schlein, Copenhagen, DK;
Anders Robert Sørensen, Herlev, DK;
Peter Madsen, Bagsværd, DK;
Thomas Børglum Kjeldsen, Virum, DK;
Morten Schlein, Copenhagen, DK;
Anders Robert Sørensen, Herlev, DK;
Peter Madsen, Bagsværd, DK;
Novo Nordisk A/S, Bagsvaerd, DK;
Abstract
The present invention is related to single-chain insulin having insulin activity comprising a B- and an A-chain or a modified B- and A-chain connected by a connecting peptide of from 6-11 amino acids. The single-chain insulins will have biological insulin activity and an IGF-1 receptor affinity similar to or lower than that of human insulin and a high physical stability. The single-chain insulin may contain at least one basic amino acid residues in the connecting peptide. The single-chain insulins may also be acylated in one or more Lys residues.