The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
Aug. 19, 2009
Michael Sela, Rehovot, IL;
Yosef Yarden, Rehovot, IL;
Bilha Schechter, Rehovot, IL;
Tsipi Ben-kasus, Beer-Sheva, IL;
Michael Sela, Rehovot, IL;
Yosef Yarden, Rehovot, IL;
Bilha Schechter, Rehovot, IL;
Tsipi Ben-Kasus, Beer-Sheva, IL;
Yeda Research and Development Co. Ltd., Rehovot, IL;
Abstract
A method of identifying a combination of antibodies with a combined improved anti-tumor activity is provided. The method comprising: (a) identifying binding epitopes of anti ErbB-2 antibodies; and (b) selecting a combination of at least two antibodies of the anti ErbB-2 antibodies exhibiting binding to different epitopes on the ErbB-2, at least one of the different epitopes being localized to a dimerization site of the ErbB-2, the combination of antibodies being with the combined improved anti-tumor activity. Also provided are novel antibody combinations uncovered according to the present teachings.