The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
May. 27, 2009
Fang Jin, San Ramon, CA (US);
Richard N. Harkins, Alameda, CA (US);
Maxine Bauzon, Hercules, CA (US);
Terry Hermiston, Corte Madera, CA (US);
Fang Jin, San Ramon, CA (US);
Richard N. Harkins, Alameda, CA (US);
Maxine Bauzon, Hercules, CA (US);
Terry Hermiston, Corte Madera, CA (US);
Bayer HealthCare LLC, Whippany, NJ (US);
Abstract
The method of the invention provides for producing a heterologous protein in mammalian host cells having nucleic acid encoding Hepatitis B X protein and the heterologous protein, by growing mammalian host cells selected from the group consisting of HKB11, CHO, BHK21, C2C12, and HEK293 cells, by growing mammalian host cells in non-adherent suspension culture, or by growing mammalian host cells which contain nucleic acid providing exogenous X-box Binding Protein, XBP1s. The conditions should be such that HBx, exogenous XBP1s if present, and the heterologous protein are expressed by the mammalian cells. The invention includes compositions for carrying out the method.