The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2014
Filed:
Jul. 06, 2010
Gianluca Mariano Enrico Papeo, Cernusco Lombardone, IT;
Alina Anatolievna Busel, Moscow, RU;
Alexander Khvat, San Diego, CA (US);
Mikhail Yurievitch Krasavin, Nathan, AU;
Barbara Forte, Milan, IT;
Fabio Zuccotto, Milan, IT;
Gianluca Mariano Enrico Papeo, Cernusco Lombardone, IT;
Alina Anatolievna Busel, Moscow, RU;
Alexander Khvat, San Diego, CA (US);
Mikhail Yurievitch Krasavin, Nathan, AU;
Barbara Forte, Milan, IT;
Fabio Zuccotto, Milan, IT;
Nerviano Medical Sciences S.R.L., Nerviano (MI), IT;
Abstract
There are provided substituted 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide derivatives (I) which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating, diseases utilizing pharmaceutical compositions comprising these compounds.