The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2014
Filed:
Apr. 23, 2008
Applicants:
Andrea Forst, Bayreuth, DE;
Philipp Hadwiger, Kulmbach, DE;
Hans-peter Vornlocher, Bayreuth, DE;
Inventors:
Assignee:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); A61K 47/48 (2006.01); C12N 15/113 (2010.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48215 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01); C12N 2310/351 (2013.01); C12N 15/113 (2013.01); C12N 15/111 (2013.01); A61K 47/48092 (2013.01);
Abstract
The present invention relates to agents, compositions and methods for inhibiting the expression of a target gene, comprising an RNAi agent bearing at least one galactosyl moiety. These are useful for delivering the gene expression inhibiting activity to cells, particularly hepatocytes, and more particularly in therapeutic applications.