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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8877896 B1

PDFFull Text
Date of Patent:
Nov. 04, 2014

Filed:

Dec. 03, 2012

Compositions, methods and kits for modeling, diagnosing, and treating complement disorders

Applicant:

Tufts University, Boston, MA (US);

Inventors:

Rajendra Kumar-Singh, Boston, MA (US);

Siobhan M. Cashman, Boston, MA (US);

John Harry Sweigard, Dorchester, MA (US);

Assignee:

Tufts University, Boston, MA (US);

Attorneys:

Lawson & Weitzen LLP

Sonia K. Guterman

Preeti T. Arun

Primary Examiner:

Daniel E Kolker

Assistant Examiner:

James Rogers

Int. Cl.
CPC ...
C07K 1/00 (2006.01); C07K 14/00 (2006.01); C07K 17/00 (2006.01); A61K 38/00 (2006.01); C12Q 1/02 (2006.01); G01N 33/564 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/025 (2013.01); G01N 2500/10 (2013.01); G01N 2800/16 (2013.01); A61K 38/00 (2013.01); G01N 2333/4716 (2013.01); G01N 33/564 (2013.01); C07K 14/70596 (2013.01);
Abstract

Systems, compositions, methods, and kits for identifying potential therapeutic agents for treatment of complement based ocular diseases are provided herein. The methods and kits include a complement component 3 (C3) protein or derivative that is contacted to ocular cells or tissue. Another embodiment of the invention herein provides for diagnosis and/or prognosis of a complement-associated ocular disease. Compositions, methods and kits for regulating or treating a complement-related condition using at least one of CD46 protein, CD55 protein, and a recombinant chimeric soluble terminator of activated complement (STAC) protein or source of the STAC protein. The STAC protein includes an amino acid sequence including at least two of an amino acid sequence of a CD59 protein, an amino acid sequence derived from a CD46 protein, and an amino acid sequence derived from a CD55 protein, optionally further comprising a linker to connect amino acid sequences.

Find Patent Forward Citations

Kumar-Singh, Rajendra. (2014). Compositions, methods and kits for modeling, diagnosing, and treating complement disorders (U.S. Patent No. 8877896). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8877896

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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