The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2014
Filed:
Mar. 25, 2011
Sudhir Agrawal, Shrewsbury, MA (US);
Ekambar Kandimalla, Hopkinton, MA (US);
Mallikarjuna Putta, Burlington, MA (US);
Ireneusz Nowak, Allston, MA (US);
Nicola Lamonica, Natick, MA (US);
Weiwen Jiang, Burlington, MA (US);
Michael Reardon, Westwood, MA (US);
Tao Lan, Winchester, MA (US);
Sudhir Agrawal, Shrewsbury, MA (US);
Ekambar Kandimalla, Hopkinton, MA (US);
Mallikarjuna Putta, Burlington, MA (US);
Ireneusz Nowak, Allston, MA (US);
Nicola LaMonica, Natick, MA (US);
Weiwen Jiang, Burlington, MA (US);
Michael Reardon, Westwood, MA (US);
Tao Lan, Winchester, MA (US);
Idera Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The inventors have examined the means for providing more efficacious miRNA blocking compounds. The inventors have discovered new structural features that surprisingly improve the efficacy of miRNA blocking molecules. These features include the presence of multiple 3' ends and a linker at the 5′ ends. Surprisingly, these features improve the efficacy of the gene expression blocking compounds in a manner that decreases the compound's biologic instability. Even more surprisingly, this effect has been found to be applicable to both DNA and RNA oligonucleotide-based compounds and to have application in traditional antisense and RNAi technology.