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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8877498 B1

PDFFull Text
Date of Patent:
Nov. 04, 2014

Filed:

Dec. 01, 2011

Porous polymer scaffolds for neural tissue engineering and methods of producing the same

Applicants:

Ulrike G.k. Wegst, Philadelphia, PA (US);

Margaret Wheatley, Media, PA (US);

Benjamin W. Riblett, Ardentown, DE (US);

Nicola Francis, Hamilton Parish, BM;

Amalie Elizabeth Donius, Alfred Station, NY (US);

Inventors:

Ulrike G.K. Wegst, Philadelphia, PA (US);

Margaret Wheatley, Media, PA (US);

Benjamin W. Riblett, Ardentown, DE (US);

Nicola Francis, Hamilton Parish, BM;

Amalie Elizabeth Donius, Alfred Station, NY (US);

Assignee:

Drexel University, Philadelphia, PA (US);

Attorneys:

Saul Ewing LLP

Kathryn Doyle

Brian R. Landry

Primary Examiner:

Susan Hanley

Assistant Examiner:

Paul Martin

Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/0793 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0619 (2013.01); C12N 2533/74 (2013.01); C12N 2533/72 (2013.01); C12N 2533/52 (2013.01); C12N 2537/00 (2013.01); C12N 2533/54 (2013.01); C12N 2533/32 (2013.01);
Abstract

The present invention relates to scaffolds that can physically guide cells, e.g. neurons, while best matching the material properties of native tissue. The present invention also relates to methods of generating such scaffolds, and for the use of such scaffolds, e.g. in spinal cord and peripheral nerve injury repair. The methods of the present invention include a uniquely controlled freeze casting process to generate highly porous, linearly oriented scaffolds. The scaffolds of the present invention not only comprise a highly aligned porosity, but also contain secondary guidance structures in the form of ridges running parallel to the pores to create a series of microstructured and highly aligned channels. This hierarchy of structural guidance aligns and guides neurite outgrowth down the channels created by the ridges, and keep neurites from branching perpendicular to the inter-ridge grooves.

Find Patent Forward Citations

Wegst, Ulrike G.K.. (2014). Porous polymer scaffolds for neural tissue engineering and methods of producing the same (U.S. Patent No. 8877498). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8877498

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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