The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2014
Filed:
Dec. 09, 2010
Method for rapidly evaluating performance of short interfering rna with novel chemical modifications
Gabor Butora, Martinsville, NJ (US);
Ian W. Davies, Princeton, NJ (US);
William Michael Flanagan, Menlo Park, CA (US);
Wenlang Fu, Florham Park, NJ (US);
Denise M. Kenski, San Francisco, CA (US);
Ning Qi, Rahway, NJ (US);
Gabor Butora, Martinsville, NJ (US);
Ian W. Davies, Princeton, NJ (US);
William Michael Flanagan, Menlo Park, CA (US);
Wenlang Fu, Florham Park, NJ (US);
Denise M. Kenski, San Francisco, CA (US);
Ning Qi, Rahway, NJ (US);
Sirna Therapeutics, Inc., Cambridge, MA (US);
Abstract
It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.