The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2014
Filed:
Nov. 15, 2010
Hira L. Nakhasi, Potomac, MD (US);
Angamuthu Selvapandiyan, Gaithersburg, MD (US);
Alain Debrabant, Silver Spring, MD (US);
Robert C. Duncan, Hyattsville, MD (US);
Poonam Salotra, New Delhi, IN;
Gannavaram Sreenivas, Rockville, MD (US);
Hira L. Nakhasi, Potomac, MD (US);
Angamuthu Selvapandiyan, Gaithersburg, MD (US);
Alain Debrabant, Silver Spring, MD (US);
Robert C. Duncan, Hyattsville, MD (US);
Poonam Salotra, New Delhi, IN;
Gannavaram Sreenivas, Rockville, MD (US);
The United States of America as Represented by the Secretary of the Department of Health and Human Services, Washington, DC (US);
Indian Council of Medical Research, New Delhi, IN;
Abstract
Targeted disruption of the centrin gene leads to attenuation of growth in the. Preferred embodiments of the invention provide attenuated strains ofuseful for the preparation of immunogenic preparations including vaccines against a disease caused by infection with a virulentstrain and as tools for the generation of immunological and diagnostic reagents. Other preferred embodiments provide related immunogenic compositions, methods of generating an immune response, methods for producing a vaccine, and methods of forming attenuated strains of