The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2014
Filed:
Dec. 08, 2011
Chung-ming Hsieh, Newton, MA (US);
Carrie L. Goodreau, Ludlow, MA (US);
Sahana Bose, Marlborough, MA (US);
Achim Moeller, Gruenstadt, DE;
Tariq Ghayur, Holliston, MA (US);
Chung-ming Hsieh, Newton, MA (US);
Carrie L. Goodreau, Ludlow, MA (US);
Sahana Bose, Marlborough, MA (US);
Achim Moeller, Gruenstadt, DE;
Tariq Ghayur, Holliston, MA (US);
AbbVie Inc., North Chicago, IL (US);
Abstract
TNF-α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-α are provided. Binding proteins have high affinity for TNF-α and neutralize TNF-α activity. A binding protein can be a full-length antibody or a TNF-α-binding portion thereof. Methods of making and methods of using the binding proteins are also described. The TNF-α binding proteins are useful for detecting TNF-α and for inhibiting TNF-α activity, including in a human subject suffering from a disease or disorder in which TNF-α activity is detrimental.