The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2014
Filed:
Sep. 04, 2008
Applicants:
Ira H. Pastan, Bethesda, MD (US);
John Weldon, Bethesda, MD (US);
David Fitzgerald, Bethesda, MD (US);
Inventors:
Ira H. Pastan, Bethesda, MD (US);
John Weldon, Bethesda, MD (US);
David FitzGerald, Bethesda, MD (US);
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/21 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/21 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01);
Abstract
The invention provides mutated, cytotoxic forms ofexotoxin A (PE) comprising a furin cleavage sequence conjugated or fused directly to residues 395-613 of PE or variants of that sequence. These minimal forms of PE are smaller than previous cytotoxic forms of PE, reduce non-specific toxicity, and reduce immunogenicity due to domain II or domain Ib of PE. The invention further provides nucleic acids encoding said PEs, chimeric molecules containing them, and methods of use thereof.