The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2014
Filed:
Jan. 19, 2009
David J. Shapiro, Urbana, IL (US);
Chengjian Mao, Savoy, IL (US);
Milu Tresa Cherian, Champaign, IL (US);
Nicole M. Patterson, Rockford, IL (US);
David J. Shapiro, Urbana, IL (US);
Chengjian Mao, Savoy, IL (US);
Milu Tresa Cherian, Champaign, IL (US);
Nicole M. Patterson, Rockford, IL (US);
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Abstract
The disclosure herein relates to nuclear hormone receptors including steroid hormone receptors, for example in connection with estrogen, progesterone, and androgen. Embodiments of compositions and methods are disclosed including such relating to compounds, including substituted theophyllines, capable of functioning as inhibitors of estrogen receptor alpha-mediated gene expression and having the ability to modify cancer cells and treat cancer, including breast cancers and resistant breast cancers, particularly those that are resistant to tamoxifen. In embodiments, methods of inhibiting breast cancer cells and resistant breast cancer cells are provided. In embodiments, a useful inhibitor compound includes TPSF/NSC 97998 and other compounds.