The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2014
Filed:
Jul. 07, 2006
Applicants:
Svetlana O. Doronina, Snohomish, WA (US);
Toni Beth Kline, Seattle, WA (US);
Scott Jeffrey, Snohomish, WA (US);
Peter D. Senter, Seattle, WA (US);
Damon Meyer, Bellevue, WA (US);
Inventors:
Svetlana O. Doronina, Snohomish, WA (US);
Toni Beth Kline, Seattle, WA (US);
Scott Jeffrey, Snohomish, WA (US);
Peter D. Senter, Seattle, WA (US);
Damon Meyer, Bellevue, WA (US);
Assignee:
Seattle Genetics, Inc., Bothell, WA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/04 (2006.01); C07K 7/02 (2006.01); C07K 5/02 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/02 (2013.01); C07K 5/0205 (2013.01); A61K 38/00 (2013.01);
Abstract
Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.