The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 28, 2014

Filed:

Nov. 17, 2010
Applicants:

Tammy Grabar, Reading, MA (US);

Wei Gong, Woburn, MA (US);

R. Rogers Yocum, Lexington, MA (US);

Inventors:

Tammy Grabar, Reading, MA (US);

Wei Gong, Woburn, MA (US);

R. Rogers Yocum, Lexington, MA (US);

Assignee:

Myriant Corporation, Quincy, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/20 (2006.01); C12N 1/00 (2006.01); C12N 15/74 (2006.01); C07H 21/04 (2006.01); C07K 14/245 (2006.01); C12P 7/46 (2006.01); C12P 7/54 (2006.01); C12P 7/40 (2006.01);
U.S. Cl.
CPC ...
C07K 14/245 (2013.01); C12P 7/46 (2013.01); C12P 7/54 (2013.01); C12P 7/40 (2013.01);
Abstract

This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids.


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