The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2014
Filed:
Mar. 22, 2011
Hans-juergen Stark, Meckesheim, DE;
Norbert Fusenig, Heidelberg, DE;
Petra Boukamp, Happenheim, DE;
Karsten Boehnke, Heidelberg, DE;
Hans-Juergen Stark, Meckesheim, DE;
Norbert Fusenig, Heidelberg, DE;
Petra Boukamp, Happenheim, DE;
Karsten Boehnke, Heidelberg, DE;
Deutsches Krebsforschungszentrum, Heidelberg, DE;
Landesstiftung Baden-Wurttemberg gGmbH, Stuttgart, DE;
Abstract
The present invention relates to organotypic cultures of epidermal cells and the use thereof for the screening of pharmaceutical and cosmetic agents. Specifically, means for the improvement of the long-term stability of such cultures are disclosed. Thus, the present invention contemplates a skin equivalent comprising (a) a dermal equivalent comprising a matrix comprising nonwoven viscose fabric and fibroblasts and (b) keratinocytes. Moreover, the present invention contemplates a method for manufacturing the skin equivalent and a method for screening agents capable of influencing skin, such as a therapeutic or cosmetic agent.